The Bacterial Sec Pathway of Protein Export
نویسندگان
چکیده
منابع مشابه
Following the leader: bacterial protein export through the Sec pathway.
Significant strides have been made during the past 20 years in our understanding of protein secretion across the bacterial inner membrane. Specialized chaperones select secretory polypeptide chains and usher them to a membrane-embedded preprotein translocase. This unique molecular machine envelops the polymeric substrate and migrates along its length in defined, energy-dependent steps. Conseque...
متن کاملOverlapping functions of components of a bacterial Sec-independent protein export pathway.
We describe the identification of two Escherichia coli genes required for the export of cofactor-containing periplasmic proteins, synthesized with signal peptides containing a twin arginine motif. Both gene products are homologous to the maize HCF106 protein required for the translocation of a subset of lumenal proteins across the thylakoid membrane. Disruption of either gene affects the export...
متن کاملBreaking on through to the other side: protein export through the bacterial Sec system.
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have invented several sophisticated secretion systems that guide various proteins to extracytoplasmic locations and in some cases inject them directly into hosts. Of these, the Sec system is ubiquitous, essential and by far the best understood. Secretory polypeptides are sorted from cytoplasmic ones initially ...
متن کاملMicroReview The Tat protein export pathway
The Tat ( twin-arginine translocation) system is a bacterial protein export pathway with the remarkable ability to transport folded proteins across the cytoplasmic membrane. Preproteins are directed to the Tat pathway by signal peptides that bear a characteristic sequence motif, which includes consecutive arginine residues. Here, we review recent progress on the characterization of the Tat syst...
متن کاملThe Cs sec mutants of Escherichia coli reflect the cold sensitivity of protein export itself.
We have found that temperature can have a striking effect upon protein export in Escherichia coli, suggesting that there is a cold-sensitive step in the protein export pathway. Cs mutations comprise the largest class of mutations affecting the membrane-localized Sec proteins SecD, SecE, SecF and SecY. Although some of these mutations could encode cold-labile proteins, this is unlikely to accoun...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2015
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057115587458